Adenovirus IgG ELISA kit can be used for the qualitative and quantitative determination of IgG antibodies against Adenovirus in human serum and plasma. The adenovirus IgG ELISA kit is shipped at ambient temperature and should be stored at 2-8°C. The microtiter strips are stable up to the expiry date of the adenovirus IgG ELISA kit in the broken, but tightly closed bag when stored at 2–8°C.
Adenovirus IgG ELISA kit is a solid phase enzyme-linked immunosorbent assay (ELISA) based on the sandwich principle. The wells of the adenovirus IgG ELISA kit are coated with antigen. Specific antibodies of the sample binding to the antigen coated wells are detected by a secondary enzyme conjugated antibody (E-Ab) specific for human IgG. After the substrate reaction the intensity of the color developed is proportional to the amount of IgG-specific antibodies detected. Results of samples can be determined directly using the standard curve.
Adenoviruses are endemic in all populations throughout the year. The infection is spread both via airborne infection or smear infection. Adenoviruses cause the widest variety of illnesses of the known respiratory viruses: diseases of the respiratory tract, pneumonia, swimming-pool-associated pharyngoconjunctival fever and epidemics of kerato-conjunctivitis. Adenoviruses mainly infest respiratory and intestinal mucosa, but also the cornea. They are accumulated in the epithelial cells and regional lymph nodes. The adenovirus is an ubiquitous pathogen of humans and animals. Many different serotypes can be distinguished.
An acute adenoviral infection can be detected by virus isolation and/or serology. The serologic tests are particularly important because they document actual infection in the patient and can be applied to largescale epidemiologic investigations. ELISA tests measure predominantly the antibodies directed against the group-specific determinants on the hexon component. Adenovirus IgG is the predominant antibody class measured in the serologic tests.
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