TBEV IgG ELISA kit is an enzyme immunoassay for the the in-vitro diagnostic qualitative and quantitative determination of IgG class antibodies against Tick-Borne Encephalitis Virus (TBEV) in human serum. TBEV IgG ELISA kit is a solid phase enzyme-linked immunosorbent assay (ELISA) based on the sandwich principle. The wells of this TBEV IgG ELISA kit are coated with antigen. Specific antibodies of the sample binding to the antigen coated wells are detected by a secondary enzyme conjugated antibody (E-Ab) specific for human IgG. After the substrate reaction the intensity of the color developed is proportional to the amount of IgG-specific antibodies detected. Results of samples can be determined directly using the standard curve.
The TBEV IgG ELISA kit is shipped at ambient temperature and should be stored at 2-8°C. Keep away from heat or direct sunlight. The storage and stability of specimen and prepared reagents is stated in the protocol insert. The microtiter strips of this TBEV IgG ELISA kit are stable up to the expiry date of the kit in the broken, but tightly closed bag when stored at 2–8°C.
The infection with TBEV occurs predominantly in early summer through the bite of a tick infected with TBEV. The incubation time ranges from 4 - 21 days. The viruses replicate in the organs of the tick, without causing symptoms of a disease or tissue damage. Characteristic for the disease is an involvement of the bulbary or cervical sections of the spinal marrow as well as the development of ascending paralysis or hemiparesis. The occurence of residual paraplegia after the infection is not uncommon. Typical infections show a two-stage course of the disease: the first phase comes along with an uncharacteristic feverish infect with strong headaches, the second phase with a meningo-encephalitis with or without pareses. If the CNS is involved, residual damage occurs in about 7% of the cases, letality is around 1%.
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