| Name |
Expression |
M. W. |
Functions |
Family |
| CD1a
CD1b
CD1c
CD1d |
Cortical
thymocytes, Langerhans cells, Dendritic cells, B cells (CD1c), Intestinal
epithelium (CD1d) |
43-49 |
MHC
class I-like molecule, associated with b2-microglobulin. May have specialised
role in antigen presentation |
Ig
superfamily (IgSF) |
| CD2 |
T
cells, thymocytes, NK cells |
45-58 |
Adhesion
molecule, binding CD58 (LFA-3). Can activate T cells |
IgSF |
| CD2R |
Activated
T cells |
45-58 |
activation-dependent
conformational form of CD2 |
IgSF |
| CD3 |
Thymocytes,
T cells |
g:25-28
d:20
e:20
z:16
h:22 |
Associated
with the T cell antigen receptor. Required for cell surface expression
of and signal transduction by TCR. |
IgSF
(gde) z/h related to FcR g chain |
| CD4 |
Thymocyte
subsets, helper and inflammatory T cells (about two thirds of peripheral
T cells), monocytes, macrophages |
55 |
Coreceptor
for MHC class II molecules. Binds lck on cytoplasmic face of membrane.
Receptor for HIV-I and HIV-2 gp120. |
IgSF |
| CD5 |
Thymocytes,
T cells, subset of B cells |
67 |
Binds
to CD72 |
Scavenger
receptor |
| CD6 |
Thymocytes,
T cells, B cell CLL |
100-130 |
unknown. |
Scavenger
receptor |
| CD7 |
Pluripotential
hematopoietic cells, thymocytes, T cells |
40 |
unknown.
Marker for T cell ALL and pluripotential stem cell leukemias |
IgSF |
| CD8 |
Thymocyte
subsets, cytotoxic T cells (about one third of peripheral T cells) |
a:
32-34
b: 32-34 |
Coreceptor
for MHC class I molecules. Binds lck on cytoplasmic face of membrane |
IgSF |
| CD9 |
Pre-B
cells, eosinophils, basophils, platelets |
22-27 |
possible
role in platelet aggregation and activation |
tetraspanning
membrane protein |
| CD10 |
B
and T cell precursors, bone marrow stromal cells |
100 |
zinc
metalloproteinase, marker for pre B ALL |
|
| CD11a |
lymphocytes,
granulocytes, monocytes and macrophages |
180 |
aL
subunit of integrin LFA-1 (associated with CD18) ; binds to CD54 (ICAM-1),
ICAM-2 and ICAM-3 |
|
| CD11b |
myeloid
and natural killer cells |
170 |
aM
subunit of integrin CR3 (associated with CD18) ; binds CD54, complement
component iC3b and extracellular matrix proteins |
|
| CD11c |
myeloid
cells |
150 |
aX
subunit of integrin CR4 (associated with CD18) ; binds fibrinogen |
|
| CDw12 |
monocytes,
granulocytes, platelets |
90-120 |
unknown |
|
| CD13 |
myelomonocytic
cells |
150-170 |
zinc
metalloproteinase |
|
| CD14 |
myelomonocytic
cells |
53-55 |
receptor
for complex of LPS and LPS binding protein (LBP) |
|
| CD15
&
CD15S |
neutrophils,
eosinophils, monocytes |
|
branched
pentasaccharide, expressed on glycolipids and many cell surface glycoproteins;
the sialylated form is a ligand for CD62E (ELAM) |
|
| CD16
A &
b |
neutrophils,
NK cells, macrophages |
50-80 |
component
of low affinity Fc receptor, FcgRIII, mediates phagocytosis and ADCC. |
IgSF |
| CDw17 |
neutrophils,
monocytes, platelets |
|
lactosyl
ceramide, a cell surface glycosphingolipid |
|
| CD18 |
Leukocytes |
95 |
integrin
b2 subunit, associates with CD11a,b and c. |
|
| CD19 |
B
cells |
95 |
forms
complex with CD21 (CR2)and CD81 (TAPA-1); coreceptor for B cells |
IgSF |
| CD20 |
B
cells |
33-37 |
possible
role in regulating B cell activation |
tetraspanning
membrane protein |
| CD21 |
mature
B cells, FDC |
145 |
receptor
for complement component C3d, EBV. With CD19 and CD81 forms coreceptor
for B cells |
complement
control protein (CCP) superfamily |
| CD22 |
mature
B cells |
a:
130
b: 140 |
Adhesion
of B cells to monocytes, T cells |
IgSF |
| CD23 |
mature
B cells, activated macrophages, eosinophils, follicular dendritic cells,
platelets |
45 |
low
affinity receptor for IgE, ligand for CD19:CD21:CD81 coreceptor |
C-type
lectin |
| CD24 |
B
cells, granulocytes |
35-45 |
unknown |
|
| CD25 |
activated
T cells, B cells, monocytes |
a:55
:b75 |
IL-2
receptor |
a:CCP
b: cytokine receptor superfamily |
| CD26 |
Activated
B and T cells, macrophages |
110 |
protease.
Recently implicated in HIV entry into cells. |
|
| CD27 |
Medullary
thymocytes, T cells |
50-55 |
unknown |
NGF
receptor superfamily |
| CD28 |
T
cell subsets, activated B cells |
44 |
Activation
of naive T cells, receptor for costimulatory signal (signal 2) binds CD80
(B7-1) and B7-2 |
IgSF |
| CD29 |
Leukocytes |
130 |
Integrin
b1 subunit, associates with CD49a in VLA-1 integrin |
|
| CD30 |
Activated
B and T cells |
105-120 |
unknown |
NGF
receptor superfamily |
| CD31 |
monocytes,
platelets, granulocytes, B cells, endothelial cells |
130-140 |
Possibly
an adhesion molecule |
IgSF |
| CDw32 |
Monocytes,
granulocytes, B cells eosinophils |
40 |
low
affinity Fc receptor for aggregated Ig/immune complexes |
IgSF |
| CD33 |
myeloid
progenitor cells, monocytes |
67 |
unknown |
IgSF |
| CD34 |
hematopoietic
precursors, capillary endothelium |
105-120 |
Ligand
for CD62 (L-selectin) |
|
| CD35 |
Erythrocytes,
B cells, monocytes, neutrophils, eosinophils, FDC |
250 |
Complement
receptor 1, binds C3B and C4b, mediates phagocytosis |
CCP
superfamily |
| CD36 |
platelets,
monocytes |
88 |
unknown |
|
| CD37 |
mature
B cells, mature T cells, myeloid cells |
40-52 |
unknown |
tetraspanning
membrane protein |
| CD38 |
early
B and T cells, activated T cells, germinal centre B cells, plasma cells |
45 |
unknown |
|
| CD39 |
activated
B cells, activated NK cells, macrophages, dendritic cells |
78 |
unknown,
may mediate adhesion of B cells |
|
| CD40 |
B
cells, monocytes, dendritic cells |
50 |
receptor
for costimulatory signal for B cells, binds CD40 Ligand (T-BAM), |
NGF
receptor superfamily |
| CD41 |
platelets,
megakaryocytes |
125/22
dimer |
aIIb
integrin, associates with CD61 to form GPIIb, binds fibrinogen, fibronectin,
von Willebrand factor and thrombospondin |
|
| CD42a,
B,c,d |
platelets,
megakaryocytes |
a:
23
b: 135, 23
c: 22
d: 85 |
binds
von Willebrand factor, thrombin; essential for platelet adhesion at sites
of injury |
|
| CD43 |
leukocytes,
except resting B cells |
115-135
(PMN)
95-115 (T cells) |
binds
CD54 (ICAM-1) |
|
| CD44 |
leukocytes,
erythrocytes |
80-95 |
binds
hyaluronic acid, mediates adhesion of leukocytes |
|
| CD45 |
leukocytes |
180-240 |
tyrosine
phosphatase, augments signalling through antigen receptor of B and T cells,
multiple isoforms result from alternative splicing (see below) |
|
| CD45RO |
T
cell subsets, B cell subsets, monocytes, macrophages |
180 |
isoform
of CD45 containing none of the A, B and C exons |
|
| CD45RA |
B
cells, T cell subsets (naive T cells) monocytes |
205-220 |
isoforms
of CD45 containing the A exon |
|
| CD45RB |
T
cell subsets, B cells, monocytes, macrophages, granulocytes |
190-220 |
isoforms
of CD45 containing the B exon |
|
| CD45RC |
Restricted
T200 |
|
|
|
| CD46 |
hematopoietic
and non-hematopoietic nucleated cells |
56/66
(splice variants) |
membrane
cofactor protein, binds to C3b and C4b to permit their degradation by
Factor I |
CCP
superfamily |
| CD47 |
all
cells |
47-52 |
unknown,
associated with Rh blood group |
|
| CD48 |
leukocytes |
40-47 |
unknown |
IgSF |
| CD49a |
activated
T cells, monocytes |
210 |
a1
integrin, associates with CD29, binds collagen, laminin |
|
| CD49b |
B
cells, monocyte, platelets |
165 |
a2
integrin, associates with CD29, binds collagen, laminin |
|
| CD49c |
B
cells |
125 |
a3
integrin, associates with CD29, bindslaminin, fibronectin |
|
| CD49d |
B
cells, thymocytes |
150 |
a4
integrin, associates with CD29, binds fibronectin, PeyerŐs Patch HEV,
VCAM-1 |
|
| CD49e |
memory
T cells, monocytes, platelets |
135,
25 dimer |
a5
integrin, associates with CD29, binds fibronectin |
|
| CD49f |
memory
T cells, thymocytes, monocytes |
120,
25 dimer |
a6integrin,
associates with CD29, binds laminin |
|
| CD50 |
thymocytes,
T cells, B cells,monocytes, granulocytes |
130 |
unknown |
|
