|
Name |
Expression |
M. W. |
Functions |
Family |
|
CD51 |
platelets, megakaryocytes |
125,24 dimer |
av integrin, associates with CD61, binds vitronectin, von Willebrand factor,
fibrinogen and thrombospondin |
|
|
CD52 |
thymocytes, T cells, B cells (not plasma cells), monocytes, granulocytes
|
21-28 |
unknown, target for antibodies used therapeutically to deplete T cells
|
|
|
CD53 |
leukocytes |
35-42 |
unknown |
tetraspanning membrane protein |
|
CD54 |
hematopoietic and non-hematopoietic cells |
85-110 |
InterCellular Adhesion Molecule, (ICAM)-1 binds CD11a/CD18 (LFA-1) and
CD11b/CD18 (Mac-1) integrins, receptor for rhinovirus |
IgSF |
|
CD55 |
hematopoietic and non-hematopoietic cells |
60-70 |
Decay Accelerating Factor (DAF), binds C3b, disassembles C3/C5 convertase
|
CCP superfamily |
|
CD56 |
NK cells |
175-185 |
isoform of Neural Cell Adhesion Molecule (NCAM), adhesion molecule
|
IgSF |
|
CD57 |
NK cells subsets of T cells, B cells and monocytes |
|
oligosaccharide, found on many cell surface glycoproteins |
|
|
CD58 |
hematopoietic and non-hematopoietic cells |
55-70 |
Leukocyte Function-associated Antigen-3 (LFA-3), binds CD2, adhesion molecule
|
IgSF |
|
CD59 |
hematopoietic and non-hematopoietic cells |
19 |
binds comlement components C8 and C9, blocks assembly of membrane attack
complex |
|
|
CD60 |
T cell subsets, platelets, monocytes |
|
oligosaccharide present on gangliosides |
|
|
CD61 |
platelets, megakaryocytes, macrophages |
105 |
Integrin b3 subunit, associates with CD41 (GPIIb/IIIa) or CD51 (vitronectin
receptor) |
|
|
CD62E |
endothelium |
140 |
endothelium leukocyte adhesion molecule (
ELAM
), bindssialyl-Lewis x, mediates rolling interaction of neutrophils
on endothelium |
C type lectin |
|
CD62L |
B cells, T cells, monocytes, NK cells |
150 |
leukocyte adhesion molecule (LAM), binds CD34, GlyCAM, mediates rolling
interactions with endothelium |
C type lectin |
|
CD62P |
platelets, megakaryocytes, endothelium |
140 |
adhesion molecule, binds sialyl Lewis x, mediates interaction of platelets
with neutrophils, monocytes and rolling interaction of neutrophils on
endothelium |
C type lectin |
|
CD63 |
activated platelets, monocytes, macrophages |
53 |
unknown, is lysosomal membrane protein translocated to cell surface after
activation |
tetraspanning membrane protein |
|
CD64 |
monocytes, macrophages |
72 |
hign affinity receptor for IgG |
IgSF |
|
CD65 |
myeloid cells |
|
Oligosaccharide component of a ceramide dodecasaccharide |
|
|
CD65s |
Ceramide dodecasaccharide 4c |
|
|
|
|
CD66a |
neutrophils |
160-180 |
unknown, member of carcinoembryonic antigen (CEA) family (see below)
|
IgSF |
|
CD66b |
granulocytes |
95-100 |
unknown, member of carcinoembryonic antigen (CEA) family |
IgSF |
|
CD66c |
neutrophils, colon carcinoma |
90 |
unknown, member of carcinoembryonic antigen (CEA) family |
IgSF |
|
CD66d |
neutrophils |
30 |
unknown, member of carcinoembryonic antigen (CEA) family |
IgSF |
|
CD66e |
adult colon epithelium, colon carcinoma |
180-200 |
unknown, member of carcinoembryonic antigen (CEA) family |
IgSF |
|
CD66f |
Pregnancy specific glycoprotein |
|
|
|
|
CD68 |
monocytes, macrophages, neutrophils, basophils, large lymphocytes
|
110 |
unknown |
|
|
CD69 |
activated B cells, activated T cells, activated macrophages, activated
NK cells |
28, 32 homo-dimer |
unknown, early activation antigen |
|
|
CD70 |
activated B cells, activated T cells, macrophages |
75,95,170 |
Unknown |
|
|
CD71 |
activated leukocytes |
90-95 homo-dimer |
transferrin receptor |
|
|
CD72 |
B cells |
42 homo-dimer |
unknown, ligand for CD5 |
C type lectin |
|
CD73 |
B cell subsets, T cell subsets |
69 |
ecto-5Õ-nucleotidase, dephosphorylates nucleotides to allow nucleoside
uptake |
|
|
CD74 |
B cells, macrophages, monocytes, MHC class II positive cells |
33,35,41,43 (alternate initiation and splicing) |
MHC class II associated Invariant chain |
|
|
CDw75 |
mature B cells, T cell subsets |
|
unknown, possibly oligosaccharide, dependent on sialylation |
|
|
CDw76 |
mature B cells, T cell subsets |
|
unknown, possibly oligosaccharide, dependent on sialylation |
|
|
CD77 |
germinal center B cells |
|
unknown, |
|
|
CDw78 |
B cells |
|
unknown |
|
|
CD79a,
CD79b
|
B cells |
a: 32-33
b: 37-39 |
Components of B cell antigen receptor analogous to CD3, required for cell
surface expression and signal transduction |
IgSF |
|
CD80 |
B cell subset |
60 |
costimulator, ligand for CD28 and CTLA-4 |
IgSF |
|
CD81 |
lymphocytes |
26 |
associates with CD19, CD21 to form B cell coreceptor |
tetraspanning membrane protein |
|
CD82 |
leukocytes |
50-53 |
unknown |
tetraspanning membrane protein |
|
CD83 |
Activated B cells, activated T cells, circulating dendritic cells (veil
cells) |
43 |
|
|
|
CDw84 |
monocytes, platelets, circulating B cells |
73 |
|
|
|
CD85 |
monocytes, circulating B cells |
120, 83 |
|
|
|
CD86 |
monocytes, activated B cells |
80 |
|
|
|
CD87 |
granulocytes, monocytes, macrophages, activated T cells |
50-65 |
Urokinase plasminogen activator receptor |
|
|
CD88 |
polymorphonuclear leukocytes, macrophages, mast cells |
40 |
Receptor for complement component C5a |
rhodopsin superfamily |
|
CD89 |
monocytes, macrophages, granulocytes, neutrophils, B cell subsets, T cell
subsets |
50-70 |
IgA receptor |
IgSF |
|
CD90 |
CD34+ prothymocytes (human) thymocytes, T cells (mouse) |
18 |
unknown |
IgSF |
|
CD91 |
monocytes |
600 |
a2 macroglobulin receptor |
|
|
CDw92 |
neutrophils, monocytes, platelets, endothelium |
70 |
unknown |
|
|
CD93 |
neutrophils, monocytes, endothelium |
120 |
unknown |
|
|
CD94 |
T cell subsets, NK cells |
43 |
unknown |
|
|
CD95 |
wide variety of cell lines in vivodistribution uncertain |
43 |
binds TNF-like ligand, induces apoptosis |
NGF receptor superfamily |
|
CD96 |
activated T cells |
160 |
Unknown |
|
|
CD97 |
activated cells |
74, 80, 90 |
unknown |
|
|
CD98 |
T cells, B cells, NK cells, granulocytes, all human cell lines
|
80, 40 |
unknown |
|
|
CD99 |
Peripheral blood lymphocytes, thymocytes |
32 |
Unknown |
|
|
CD100 |
Broad expression on haematopoietic cells |
150 |
Unknown |
|
