ANGPT3 Human (Angiopoietin 5)
Synonyms: ANGPT5, Angiopoietin 5, Angiopoietin Like Protein 3, ANGPTL3
- Belongs to the secreted factor family of proteins and is found to be predominantly expressed in the liver.
- Its main function is in the process of regulating the inhibition of lipolysis of triglycerides. This is carried out mainly by Lipoprotein lipase differential inhibition by either Angptl3 and Angptl4 during fasting and feeding nutritional states.
- Structure has been shown to be similar to the other angiopoietins family members.
- Furthermore, experimental studies have shown that it is the amino terminal which was responsible for the elevated plasma levels of triglyceride in mice.
Source: E. Coli.
Specificity: Homologous (100%) to a.a. sequence 17-223 of the Human ANGPTL3 precursor minus the signal sequence.
Purification Method: One-step using Ni-NTA chromatography.
Formulation: Lyophilized and sterile filtered from 0.5 mg/ml in 0.05M Acetate buffer pH-4.
Solubility: Dissolve lyophilized pellet fully in 0.2 ml of 0.1M Acetate buffer pH-4.
Stability: Store lyophilized at -20°C for long term storage and 4°C for short term. Please avoid repeated freezing/thawing cycles.
Purity: Above 95% as determined by SDS-PAGE.
Application: ELISA and Western blot analysis.
Amino Acid Sequence:
MRGSHHHHHH GMASHMSRID QDNSSFDSLS PEPKSRFAML DDVKILANGL LQLGHGLKDF VHKTKGQIND IFQKLNIFDQ SFYDLSLQTS EIKEEEKELR RTTYKLQVKN EEVKNMSLEL NSKLESLLEE KILLQQKVKY LEEQLTNLIQ NQPETPEHPE VTSLKTFVEK QDNSIKDLLQ TVEDQYKQLN QQHSQIKEIE NQLRRTSIQE PTEISLSSKP RAP.
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